Have any TV shows spawned spin-offs of a different genre?

This thread gives some examples, including the following:

• Lou Grant was a drama that spun off from the sitcom The Mary Tyler Moore Show (this was already mentioned in an answer by Walt)

• The Perry Mason radio show was a soap opera/drama that spawned two TV series. The Edge of Night came first and was a soap opera/drama. A year later came Perry Mason, which was just a drama.

• Trapper John, M.D. was a drama that spun off from the comedy film MASH (it was legally determined to not be a spin-off of the M*A*S*H TV series).

• Fernwood 2 Night was a parody talk show that spun off from the soap opera parody Mary Hartman, Mary Hartman.

• Nick & Hillary was a sitcom that was a spin-off/transformation of the Tattingers comedy/drama.

• Boston Legal was a comedy/drama that was spun off from the drama The Practice.

• Mama's Family was a sitcom that spun off from the sketch comedy shows The Carol Burnette Show and Carol & Company.

I think an interesting example in this regard might be Baywatch Nights, which was basically a detective crime show, with Mitch Buchannon opening a private investigation agency. I would call this quite a contrast to the rather soap-opera-like lifeguard drama of the original Baywatch this was a spin-off to. And if this wasn't enough, the whole concept of Baywatch Nights was changed in the 2nd season to a downright mystery show having to cope with things like paranormal activities, strange goo monsters on oil rigs and deadly stardust. If that isn't a stark contrast to good old Baywatch, I don't know what is.

Yes. Off the top of my head, Lou Grant from 1977 was a drama series, yet it was a spin-off of the sitcom The Mary Tyler Moore Show. [And dang it, I was going to mention Baywatch Nights too! ;)]

It also worked the other way in the more obscure example of Beverly Hills Buntz, an NBC comedy with Denis Frantz that ran for one season in the late 80s and was a spin off of cop drama Hill Street Blues.

JAG (U.S. military acronym for Judge Advocate General) is an American legal drama television show with a distinct U.S. Navy theme. It spun off NCIS. NCIS is an American police procedural drama television series, revolving around a fictional team of special agents from the Naval Criminal Investigative Service, which conducts criminal investigations involving the U.S. Navy and Marine Corps.

X-Files spun off The Lone Gunmen. X-Files being about Alien conspiracy while the latter being about regular conspiracies.

The Teen Titans cartoon was a action-adventure superhero series. It's spin-off Teen Titans Go! is a slapstick variety show.

Space Ghost was a superhero villain of the week show. It Spun off to Space Ghost Coast to Coast, a parody talk show. THAT spun off the Brak Show, a sitcom.

The biggest difference in genre that I can think of: The Simpsons is an animated spin-off from the sketch comedy show The Tracey Ullman Show.

Labeling genre can be subjective.

Here's my rationale...

Genre is defined as: "a categorization of a category of artistic composition, as in music or literature, characterized by similarities in form, style, or subject matter".

The form style and subject differences between The Tracey Ullman Show and The Simpsons are huge:

Form: The Tracey Ullman Show is live action, The Simpsons is animated.

Style: The Tracey Ullman Show is sketch-comedy/variety, The Simpsons is a 30 minute sit-com.

Subject: The Tracey Ullman Show is based on non-related segments. The Simpsons is based on developing recurring characters of an entire city...and indeed has succeeded in building an entire universe.

Darkwing Duck is a spin-off of DuckTales, and while they aren't COMPLETELY different genres, DuckTales is more of an "adventure" story revolving around three kids, while Darkwing Duck is a crime-fighting superhero story revolving around an adult and his daughter.